Cargando…
Mutations that disrupt Ca(2+)-binding activity endow Doc2β with novel functional properties during synaptic transmission
Double C2-domain protein (Doc2) is a Ca(2+)-binding protein implicated in asynchronous and spontaneous neurotransmitter release. Here we demonstrate that each of its C2 domains senses Ca(2+); moreover, the tethered tandem C2 domains display properties distinct from the isolated domains. We confirm t...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923640/ https://www.ncbi.nlm.nih.gov/pubmed/24356452 http://dx.doi.org/10.1091/mbc.E13-10-0571 |