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A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker

Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and the role of lichen sclerosus and c-KIT mutations in the aeti...

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Autores principales: HEINZELMANN-SCHWARZ, VIOLA A., NIXDORF, SHERI, VALADAN, MEHRNAZ, DICZBALIS, MONICA, OLIVIER, JAKE, OTTON, GEOFF, FEDIER, ANDRÉ, HACKER, NEVILLE F., SCURRY, JAMES P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976128/
https://www.ncbi.nlm.nih.gov/pubmed/24535703
http://dx.doi.org/10.3892/ijmm.2014.1659
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author HEINZELMANN-SCHWARZ, VIOLA A.
NIXDORF, SHERI
VALADAN, MEHRNAZ
DICZBALIS, MONICA
OLIVIER, JAKE
OTTON, GEOFF
FEDIER, ANDRÉ
HACKER, NEVILLE F.
SCURRY, JAMES P.
author_facet HEINZELMANN-SCHWARZ, VIOLA A.
NIXDORF, SHERI
VALADAN, MEHRNAZ
DICZBALIS, MONICA
OLIVIER, JAKE
OTTON, GEOFF
FEDIER, ANDRÉ
HACKER, NEVILLE F.
SCURRY, JAMES P.
author_sort HEINZELMANN-SCHWARZ, VIOLA A.
collection PubMed
description Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and the role of lichen sclerosus and c-KIT mutations in the aetiology of vulvar melanoma is unclear. Breslow staging currently seems to be the most adequate predictor of prognosis. We thus performed a clinicopathological and literature review to identify suitable predictors of prognosis and survival and investigated the expression of c-KIT (by immunohistochemistry) in patients with vulvar melanoma (n=33) from the Gynaecological Cancer Centres of the Royal Hospital for Women (Sydney, Australia) and John Hunter Hospital (Newcastle, Australia). Our series of 33 patients fitted the expected clinical profile of older women: delayed presentation, high stage, limited response to treatment and poor prognosis. We identified 3 patients (9.1%) with lichen sclerosus associated with melanoma in situ, although no lichen sclerosus was found in the areas of invasive melanoma. No patient had vulvar nevi. We identified a) Breslow’s depth, b) an absence of any of the pathological risk factors, such as satellitosis, in-transit metastasis, lymphovascular space invasion (LVSI) and dermal mitosis, c) removal of inguino-femoral lymph nodes, d) lateral margin of >1 cm, and e) c-KIT expression as valuable prognostic predictors for disease-free survival. We conclude that c-KIT expression is, apart from Breslow’s depth, another valuable predictor of prognosis and survival. Lichen sclerosus may be associated with vulvar melanoma.
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spelling pubmed-39761282014-04-04 A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker HEINZELMANN-SCHWARZ, VIOLA A. NIXDORF, SHERI VALADAN, MEHRNAZ DICZBALIS, MONICA OLIVIER, JAKE OTTON, GEOFF FEDIER, ANDRÉ HACKER, NEVILLE F. SCURRY, JAMES P. Int J Mol Med Articles Vulvar melanoma is the second most common vulvar cancer. Patients with vulvar melanoma usually present with the disease at a late stage and have a poor prognosis. The prognostic predictors reported in the literature are not unequivocal and the role of lichen sclerosus and c-KIT mutations in the aetiology of vulvar melanoma is unclear. Breslow staging currently seems to be the most adequate predictor of prognosis. We thus performed a clinicopathological and literature review to identify suitable predictors of prognosis and survival and investigated the expression of c-KIT (by immunohistochemistry) in patients with vulvar melanoma (n=33) from the Gynaecological Cancer Centres of the Royal Hospital for Women (Sydney, Australia) and John Hunter Hospital (Newcastle, Australia). Our series of 33 patients fitted the expected clinical profile of older women: delayed presentation, high stage, limited response to treatment and poor prognosis. We identified 3 patients (9.1%) with lichen sclerosus associated with melanoma in situ, although no lichen sclerosus was found in the areas of invasive melanoma. No patient had vulvar nevi. We identified a) Breslow’s depth, b) an absence of any of the pathological risk factors, such as satellitosis, in-transit metastasis, lymphovascular space invasion (LVSI) and dermal mitosis, c) removal of inguino-femoral lymph nodes, d) lateral margin of >1 cm, and e) c-KIT expression as valuable prognostic predictors for disease-free survival. We conclude that c-KIT expression is, apart from Breslow’s depth, another valuable predictor of prognosis and survival. Lichen sclerosus may be associated with vulvar melanoma. D.A. Spandidos 2014-04 2014-02-14 /pmc/articles/PMC3976128/ /pubmed/24535703 http://dx.doi.org/10.3892/ijmm.2014.1659 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
HEINZELMANN-SCHWARZ, VIOLA A.
NIXDORF, SHERI
VALADAN, MEHRNAZ
DICZBALIS, MONICA
OLIVIER, JAKE
OTTON, GEOFF
FEDIER, ANDRÉ
HACKER, NEVILLE F.
SCURRY, JAMES P.
A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker
title A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker
title_full A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker
title_fullStr A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker
title_full_unstemmed A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker
title_short A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker
title_sort clinicopathological review of 33 patients with vulvar melanoma identifies c-kit as a prognostic marker
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976128/
https://www.ncbi.nlm.nih.gov/pubmed/24535703
http://dx.doi.org/10.3892/ijmm.2014.1659
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