Blockade of Lysosomal Acid Ceramidase Induces GluN2B-Dependent Tau Phosphorylation in Rat Hippocampal Slices

The lysosomal acid ceramidase, an enzyme known to limit intracellular ceramide accumulation, has been reported to be defective in neurodegenerative disorders. We show here that rat hippocampal slices, preincubated with the acid ceramidase inhibitor (ACI) d-NMAPPD, exhibit increased N-methyl-D-aspart...

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Detalles Bibliográficos
Autores principales: Laurier-Laurin, Marie-Elaine, De Montigny, Audrée, Attiori Essis, Suzanne, Cyr, Michel, Massicotte, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170924/
https://www.ncbi.nlm.nih.gov/pubmed/25276436
http://dx.doi.org/10.1155/2014/196812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170924/
https://www.ncbi.nlm.nih.gov/pubmed/25276436
http://dx.doi.org/10.1155/2014/196812

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