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No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans

Non-African populations have experienced size reductions in the time since their split from West Africans, leading to the hypothesis that natural selection to remove weakly deleterious mutations has been less effective in the history of non-Africans. To test this hypothesis, we measured the per-geno...

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Detalles Bibliográficos
Autores principales: Do, Ron, Balick, Daniel, Li, Heng, Adzhubei, Ivan, Sunyaev, Shamil, Reich, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310772/
https://www.ncbi.nlm.nih.gov/pubmed/25581429
http://dx.doi.org/10.1038/ng.3186