The role of microtubule-associated protein 1B in axonal growth and neuronal migration in the central nervous system☆

In this review, we discuss the role of microtubule-associated protein 1B (MAP1B) and its phosphorylation in axonal development and regeneration in the central nervous system. MAP1B exhibits similar functions during axonal development and regeneration. MAP1B and phosphorylated MAP1B in neurons and ax...

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Detalles Bibliográficos
Autores principales: Yang, Maoguang, Wu, Minfei, Xia, Peng, Wang, Chunxin, Yan, Peng, Gao, Qi, Liu, Jian, Wang, Haitao, Duan, Xingwei, Yang, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342712/
https://www.ncbi.nlm.nih.gov/pubmed/25737712
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.11.008
Descripción
Sumario:In this review, we discuss the role of microtubule-associated protein 1B (MAP1B) and its phosphorylation in axonal development and regeneration in the central nervous system. MAP1B exhibits similar functions during axonal development and regeneration. MAP1B and phosphorylated MAP1B in neurons and axons maintain a dynamic balance between cytoskeletal components, and regulate the stability and interaction of microtubules and actin to promote axonal growth, neural connectivity and regeneration in the central nervous system.

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