MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications

MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma...

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Autores principales: Sana, Jiri, Hajduch, Marian, Michalek, Jaroslav, Vyzula, Rostislav, Slaby, Ondrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373357/
https://www.ncbi.nlm.nih.gov/pubmed/21435175
http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x
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author Sana, Jiri
Hajduch, Marian
Michalek, Jaroslav
Vyzula, Rostislav
Slaby, Ondrej
author_facet Sana, Jiri
Hajduch, Marian
Michalek, Jaroslav
Vyzula, Rostislav
Slaby, Ondrej
author_sort Sana, Jiri
collection PubMed
description MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.
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spelling pubmed-43733572015-04-06 MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications Sana, Jiri Hajduch, Marian Michalek, Jaroslav Vyzula, Rostislav Slaby, Ondrej J Cell Mol Med Reviews MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications. Blackwell Publishing Ltd 2011-08 2011-07-13 /pmc/articles/PMC4373357/ /pubmed/21435175 http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x Text en © 2011 The Authors Journal compilation © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
Sana, Jiri
Hajduch, Marian
Michalek, Jaroslav
Vyzula, Rostislav
Slaby, Ondrej
MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
title MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
title_full MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
title_fullStr MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
title_full_unstemmed MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
title_short MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
title_sort micrornas and glioblastoma: roles in core signalling pathways and potential clinical implications
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373357/
https://www.ncbi.nlm.nih.gov/pubmed/21435175
http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x
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