MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373357/ https://www.ncbi.nlm.nih.gov/pubmed/21435175 http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x |
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author | Sana, Jiri Hajduch, Marian Michalek, Jaroslav Vyzula, Rostislav Slaby, Ondrej |
author_facet | Sana, Jiri Hajduch, Marian Michalek, Jaroslav Vyzula, Rostislav Slaby, Ondrej |
author_sort | Sana, Jiri |
collection | PubMed |
description | MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications. |
format | Online Article Text |
id | pubmed-4373357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43733572015-04-06 MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications Sana, Jiri Hajduch, Marian Michalek, Jaroslav Vyzula, Rostislav Slaby, Ondrej J Cell Mol Med Reviews MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications. Blackwell Publishing Ltd 2011-08 2011-07-13 /pmc/articles/PMC4373357/ /pubmed/21435175 http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x Text en © 2011 The Authors Journal compilation © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Reviews Sana, Jiri Hajduch, Marian Michalek, Jaroslav Vyzula, Rostislav Slaby, Ondrej MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications |
title | MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications |
title_full | MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications |
title_fullStr | MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications |
title_full_unstemmed | MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications |
title_short | MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications |
title_sort | micrornas and glioblastoma: roles in core signalling pathways and potential clinical implications |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373357/ https://www.ncbi.nlm.nih.gov/pubmed/21435175 http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x |
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