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Convergent and divergent mechanisms of sugar recognition across kingdoms
Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444583/ https://www.ncbi.nlm.nih.gov/pubmed/25102772 http://dx.doi.org/10.1016/j.sbi.2014.07.003 |
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author | Taylor, Maureen E Drickamer, Kurt |
author_facet | Taylor, Maureen E Drickamer, Kurt |
author_sort | Taylor, Maureen E |
collection | PubMed |
description | Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the problem of distinguishing sugars with closely similar structures and binding them with sufficient affinity to achieve biologically meaningful results. Structural and functional analysis has revealed striking parallels between protein domains with widely different structures and evolutionary histories that employ common solutions to the sugar recognition problem. Recent studies also demonstrate that domains descended from common ancestors through divergent evolution appear more widely across the kingdoms of life than had previously been recognized. |
format | Online Article Text |
id | pubmed-4444583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44445832015-05-29 Convergent and divergent mechanisms of sugar recognition across kingdoms Taylor, Maureen E Drickamer, Kurt Curr Opin Struct Biol Article Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the problem of distinguishing sugars with closely similar structures and binding them with sufficient affinity to achieve biologically meaningful results. Structural and functional analysis has revealed striking parallels between protein domains with widely different structures and evolutionary histories that employ common solutions to the sugar recognition problem. Recent studies also demonstrate that domains descended from common ancestors through divergent evolution appear more widely across the kingdoms of life than had previously been recognized. Elsevier Science 2014-10 /pmc/articles/PMC4444583/ /pubmed/25102772 http://dx.doi.org/10.1016/j.sbi.2014.07.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Taylor, Maureen E Drickamer, Kurt Convergent and divergent mechanisms of sugar recognition across kingdoms |
title | Convergent and divergent mechanisms of sugar recognition across kingdoms |
title_full | Convergent and divergent mechanisms of sugar recognition across kingdoms |
title_fullStr | Convergent and divergent mechanisms of sugar recognition across kingdoms |
title_full_unstemmed | Convergent and divergent mechanisms of sugar recognition across kingdoms |
title_short | Convergent and divergent mechanisms of sugar recognition across kingdoms |
title_sort | convergent and divergent mechanisms of sugar recognition across kingdoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444583/ https://www.ncbi.nlm.nih.gov/pubmed/25102772 http://dx.doi.org/10.1016/j.sbi.2014.07.003 |
work_keys_str_mv | AT taylormaureene convergentanddivergentmechanismsofsugarrecognitionacrosskingdoms AT drickamerkurt convergentanddivergentmechanismsofsugarrecognitionacrosskingdoms |