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Convergent and divergent mechanisms of sugar recognition across kingdoms

Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the p...

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Detalles Bibliográficos
Autores principales: Taylor, Maureen E, Drickamer, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444583/
https://www.ncbi.nlm.nih.gov/pubmed/25102772
http://dx.doi.org/10.1016/j.sbi.2014.07.003
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author Taylor, Maureen E
Drickamer, Kurt
author_facet Taylor, Maureen E
Drickamer, Kurt
author_sort Taylor, Maureen E
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description Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the problem of distinguishing sugars with closely similar structures and binding them with sufficient affinity to achieve biologically meaningful results. Structural and functional analysis has revealed striking parallels between protein domains with widely different structures and evolutionary histories that employ common solutions to the sugar recognition problem. Recent studies also demonstrate that domains descended from common ancestors through divergent evolution appear more widely across the kingdoms of life than had previously been recognized.
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spelling pubmed-44445832015-05-29 Convergent and divergent mechanisms of sugar recognition across kingdoms Taylor, Maureen E Drickamer, Kurt Curr Opin Struct Biol Article Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the problem of distinguishing sugars with closely similar structures and binding them with sufficient affinity to achieve biologically meaningful results. Structural and functional analysis has revealed striking parallels between protein domains with widely different structures and evolutionary histories that employ common solutions to the sugar recognition problem. Recent studies also demonstrate that domains descended from common ancestors through divergent evolution appear more widely across the kingdoms of life than had previously been recognized. Elsevier Science 2014-10 /pmc/articles/PMC4444583/ /pubmed/25102772 http://dx.doi.org/10.1016/j.sbi.2014.07.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Taylor, Maureen E
Drickamer, Kurt
Convergent and divergent mechanisms of sugar recognition across kingdoms
title Convergent and divergent mechanisms of sugar recognition across kingdoms
title_full Convergent and divergent mechanisms of sugar recognition across kingdoms
title_fullStr Convergent and divergent mechanisms of sugar recognition across kingdoms
title_full_unstemmed Convergent and divergent mechanisms of sugar recognition across kingdoms
title_short Convergent and divergent mechanisms of sugar recognition across kingdoms
title_sort convergent and divergent mechanisms of sugar recognition across kingdoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444583/
https://www.ncbi.nlm.nih.gov/pubmed/25102772
http://dx.doi.org/10.1016/j.sbi.2014.07.003
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