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Wnt ligand–dependent activation of the negative feedback regulator Nkd1

Misregulation of Wnt signaling is at the root of many diseases, most notably colorectal cancer, and although we understand the activation of the pathway, we have a very poor understanding of the circumstances under which Wnt signaling turns itself off. There are numerous negative feedback regulators...

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Detalles Bibliográficos
Autores principales: Larraguibel, Jahdiel, Weiss, Alexander R. E., Pasula, Daniel J., Dhaliwal, Rasmeet S., Kondra, Roman, Van Raay, Terence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462952/
https://www.ncbi.nlm.nih.gov/pubmed/25904337
http://dx.doi.org/10.1091/mbc.E14-12-1648