DNA methylation mediated silencing of microRNA-145 is a potential prognostic marker in patients with lung adenocarcinoma

The molecular mechanism of down-regulated microRNA-145 (miR-145) expression in lung adenocarcinoma (LAC) remains largely unknown. We hypothesized that aberrant hyper-methylation of the CpG sites silenced the expression of miR-145 in LAC. In consideration of its pivotal role in LAC development and pr...

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Detalles Bibliográficos
Autores principales: Xia, Wenjie, Chen, Qiang, Wang, Jie, Mao, Qixing, Dong, Gaochao, Shi, Run, Zheng, YanYan, Xu, Lin, Jiang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652277/
https://www.ncbi.nlm.nih.gov/pubmed/26582602
http://dx.doi.org/10.1038/srep16901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652277/
https://www.ncbi.nlm.nih.gov/pubmed/26582602
http://dx.doi.org/10.1038/srep16901

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