Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas

The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we exami...

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Autores principales: Xiao, Desheng, Jia, Jiantao, Shi, Ying, Fu, Chunyan, Chen, Ling, Jiang, Yiqun, Zhou, Li, Liu, Shuang, Tao, Yongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694847/
https://www.ncbi.nlm.nih.gov/pubmed/26317791
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author Xiao, Desheng
Jia, Jiantao
Shi, Ying
Fu, Chunyan
Chen, Ling
Jiang, Yiqun
Zhou, Li
Liu, Shuang
Tao, Yongguang
author_facet Xiao, Desheng
Jia, Jiantao
Shi, Ying
Fu, Chunyan
Chen, Ling
Jiang, Yiqun
Zhou, Li
Liu, Shuang
Tao, Yongguang
author_sort Xiao, Desheng
collection PubMed
description The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlateed with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer.
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spelling pubmed-46948472016-01-20 Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas Xiao, Desheng Jia, Jiantao Shi, Ying Fu, Chunyan Chen, Ling Jiang, Yiqun Zhou, Li Liu, Shuang Tao, Yongguang Oncotarget Research Paper The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlateed with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer. Impact Journals LLC 2015-08-06 /pmc/articles/PMC4694847/ /pubmed/26317791 Text en Copyright: © 2015 Xiao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xiao, Desheng
Jia, Jiantao
Shi, Ying
Fu, Chunyan
Chen, Ling
Jiang, Yiqun
Zhou, Li
Liu, Shuang
Tao, Yongguang
Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
title Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
title_full Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
title_fullStr Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
title_full_unstemmed Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
title_short Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
title_sort opposed expression of ikkα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694847/
https://www.ncbi.nlm.nih.gov/pubmed/26317791
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