Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we exami...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694847/ https://www.ncbi.nlm.nih.gov/pubmed/26317791 |
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author | Xiao, Desheng Jia, Jiantao Shi, Ying Fu, Chunyan Chen, Ling Jiang, Yiqun Zhou, Li Liu, Shuang Tao, Yongguang |
author_facet | Xiao, Desheng Jia, Jiantao Shi, Ying Fu, Chunyan Chen, Ling Jiang, Yiqun Zhou, Li Liu, Shuang Tao, Yongguang |
author_sort | Xiao, Desheng |
collection | PubMed |
description | The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlateed with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer. |
format | Online Article Text |
id | pubmed-4694847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-46948472016-01-20 Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas Xiao, Desheng Jia, Jiantao Shi, Ying Fu, Chunyan Chen, Ling Jiang, Yiqun Zhou, Li Liu, Shuang Tao, Yongguang Oncotarget Research Paper The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlateed with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer. Impact Journals LLC 2015-08-06 /pmc/articles/PMC4694847/ /pubmed/26317791 Text en Copyright: © 2015 Xiao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xiao, Desheng Jia, Jiantao Shi, Ying Fu, Chunyan Chen, Ling Jiang, Yiqun Zhou, Li Liu, Shuang Tao, Yongguang Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas |
title | Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas |
title_full | Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas |
title_fullStr | Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas |
title_full_unstemmed | Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas |
title_short | Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas |
title_sort | opposed expression of ikkα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694847/ https://www.ncbi.nlm.nih.gov/pubmed/26317791 |
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