Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells

In this study, we investigated the potential anticancer effects of calycosin against human glioblastoma cells, including the impacts on cell proliferation, apoptosis, and cell cycle distribution. We further studied its inhibitory activity on migration and invasion in U87 and U251 cells. Furthermore,...

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Detalles Bibliográficos
Autores principales: Nie, Xiao-hu, Ou-yang, Jia, Xing, Ying, Li, Dan-yan, Liu, Ru-en, Xu, Ru-xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769008/
https://www.ncbi.nlm.nih.gov/pubmed/26955262
http://dx.doi.org/10.2147/DDDT.S90457
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author Nie, Xiao-hu
Ou-yang, Jia
Xing, Ying
Li, Dan-yan
Liu, Ru-en
Xu, Ru-xiang
author_facet Nie, Xiao-hu
Ou-yang, Jia
Xing, Ying
Li, Dan-yan
Liu, Ru-en
Xu, Ru-xiang
author_sort Nie, Xiao-hu
collection PubMed
description In this study, we investigated the potential anticancer effects of calycosin against human glioblastoma cells, including the impacts on cell proliferation, apoptosis, and cell cycle distribution. We further studied its inhibitory activity on migration and invasion in U87 and U251 cells. Furthermore, transforming growth factor beta-mediated reductions of mesenchymal-associated genes/activators, matrix metalloproteinases-2, and -9 were detected in this process. Administration of calycosin in a glioblastoma xenograft model showed that calycosin could not only reduce tumor volume but also suppress transforming growth factor beta as well as its downstream molecules. These results revealed calycosin as a potential antitumor agent in human glioblastoma.
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spelling pubmed-47690082016-03-07 Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells Nie, Xiao-hu Ou-yang, Jia Xing, Ying Li, Dan-yan Liu, Ru-en Xu, Ru-xiang Drug Des Devel Ther Original Research In this study, we investigated the potential anticancer effects of calycosin against human glioblastoma cells, including the impacts on cell proliferation, apoptosis, and cell cycle distribution. We further studied its inhibitory activity on migration and invasion in U87 and U251 cells. Furthermore, transforming growth factor beta-mediated reductions of mesenchymal-associated genes/activators, matrix metalloproteinases-2, and -9 were detected in this process. Administration of calycosin in a glioblastoma xenograft model showed that calycosin could not only reduce tumor volume but also suppress transforming growth factor beta as well as its downstream molecules. These results revealed calycosin as a potential antitumor agent in human glioblastoma. Dove Medical Press 2016-02-22 /pmc/articles/PMC4769008/ /pubmed/26955262 http://dx.doi.org/10.2147/DDDT.S90457 Text en © 2016 Nie et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Nie, Xiao-hu
Ou-yang, Jia
Xing, Ying
Li, Dan-yan
Liu, Ru-en
Xu, Ru-xiang
Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
title Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
title_full Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
title_fullStr Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
title_full_unstemmed Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
title_short Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
title_sort calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in u87 and u251 cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769008/
https://www.ncbi.nlm.nih.gov/pubmed/26955262
http://dx.doi.org/10.2147/DDDT.S90457
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