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Novel Types of Small RNA Exhibit Sequence- and Target-dependent Angiogenesis Suppression Without Activation of Toll-like Receptor 3 in an Age-related Macular Degeneration (AMD) Mouse Model
RNA interference (RNAi) has become a powerful tool for suppressing gene expression in vitro and in vivo. A great deal of evidence has demonstrated the potential for the use of synthetic small interfering RNAs (siRNAs) as therapeutic agents. However, the application of siRNA to clinical medicine is s...
Autores principales: | Takanashi, Masakatsu, Sudo, Katsuko, Ueda, Shinobu, Ohno, Shin-Ichiro, Yamada, Yuko, Osakabe, Yasuhiro, Goto, Hiroshi, Matsunaga, Yoshimichi, Ishikawa, Akio, Usui, Yoshihiko, Kuroda, Masahiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881762/ https://www.ncbi.nlm.nih.gov/pubmed/26484944 http://dx.doi.org/10.1038/mtna.2015.34 |
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