Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Chao, Li, Xue, Yu, Fei, Lu, Lu, Jiang, Xifeng, Xu, Xiaoyu, Wang, Huixin, Lai, Wenqing, Zhang, Tianhong, Zhang, Zhenqing, Ye, Ling, Jiang, Shibo, Liu, Keliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999862/
https://www.ncbi.nlm.nih.gov/pubmed/27562370
http://dx.doi.org/10.1038/srep32161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999862/
https://www.ncbi.nlm.nih.gov/pubmed/27562370
http://dx.doi.org/10.1038/srep32161

Ejemplares similares