Cargando…
Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing
BACKGROUND: Targeted next generation sequencing (tNGS) has become part of molecular pathology diagnostics for determining RAS mutation status in colorectal cancer (CRC) patients as predictive tool for decision on EGFR-targeted therapy. Here, we investigated mutation profiles of case-matched tissue s...
Autores principales: | Kovaleva, Valentina, Geissler, Anna-Lena, Lutz, Lisa, Fritsch, Ralph, Makowiec, Frank, Wiesemann, Sebastian, Hopt, Ulrich T., Passlick, Bernward, Werner, Martin, Lassmann, Silke |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069823/ https://www.ncbi.nlm.nih.gov/pubmed/27756406 http://dx.doi.org/10.1186/s12943-016-0549-8 |
Ejemplares similares
-
ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer
por: Geißler, Anna-Lena, et al.
Publicado: (2017) -
Mutational signatures of synchronous and metachronous brain metastases from lung adenocarcinoma
por: Chen, Jianing, et al.
Publicado: (2023) -
Differences in clinical characteristics and mutational pattern between synchronous and metachronous colorectal liver metastases
por: Zheng, Peng, et al.
Publicado: (2018) -
Lung Resections for Elderly Patients with Lung Metastases: A Comparative Study of the Postoperative Complications and Overall Survival
por: Hassan, Mohamed, et al.
Publicado: (2022) -
Study Protocol for a Randomised Controlled Trial on Pulmonary Metastasectomy vs. Standard of Care in Colorectal Cancer Patients With ≥ 3 Lung Metastases (PUCC-Trial)
por: Schmid, Severin, et al.
Publicado: (2022)