Emerin Caps the Pointed End of Actin Filaments: Evidence for an Actin Cortical Network at the Nuclear Inner Membrane

X-linked Emery-Dreifuss muscular dystrophy is caused by loss of emerin, a LEM-domain protein of the nuclear inner membrane. To better understand emerin function, we used affinity chromatography to purify emerin-binding proteins from nuclear extracts of HeLa cells. Complexes that included actin, αII-...

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Detalles Bibliográficos
Autores principales: Holaska, James M, Kowalski, Amy K, Wilson, Katherine L
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC509406/
https://www.ncbi.nlm.nih.gov/pubmed/15328537
http://dx.doi.org/10.1371/journal.pbio.0020231