A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (Acc1p) is a key enzyme in fatty acid biosynthesis and is essential for cell viability. To discover new regulators of its activity, we screened a Saccharomyces cerevisiae deletion library for increased sensitivity to soraphen A, a potent Acc1p inhibitor. The hits identified in...

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Detalles Bibliográficos
Autores principales: Bozaquel-Morais, Bruno L., Madeira, Juliana B., Venâncio, Thiago M., Pacheco-Rosa, Thiago, Masuda, Claudio A., Montero-Lomeli, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226726/
https://www.ncbi.nlm.nih.gov/pubmed/28076367
http://dx.doi.org/10.1371/journal.pone.0169682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226726/
https://www.ncbi.nlm.nih.gov/pubmed/28076367
http://dx.doi.org/10.1371/journal.pone.0169682

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