Acute plasma tau relates to prolonged return to play after concussion

OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and...

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Detalles Bibliográficos
Autores principales: Gill, Jessica, Merchant-Borna, Kian, Jeromin, Andreas, Livingston, Whitney, Bazarian, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304458/
https://www.ncbi.nlm.nih.gov/pubmed/28062722
http://dx.doi.org/10.1212/WNL.0000000000003587
Descripción
Sumario:OBJECTIVE: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP). METHODS: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay. RESULTS: Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F(101,3) = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F(39,1) = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62–0.97, p = 0.01). CONCLUSIONS: Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP.