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Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women

PURPOSE: Healthy microcirculation is important to maintain the health of tissues and organs, most notably the heart, kidney and retina. Single components of the diet such as salt, lipids and polyphenols may influence microcirculation, but the effects of dietary patterns that are consistent with curr...

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Autores principales: Govoni, Virginia, Sanders, Thomas A. B., Reidlinger, Dianne P., Darzi, Julia, Berry, Sarah E. E., Goff, Louise M., Seed, Paul T., Chowienczyk, Philip J., Hall, Wendy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346414/
https://www.ncbi.nlm.nih.gov/pubmed/26746219
http://dx.doi.org/10.1007/s00394-015-1151-3
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author Govoni, Virginia
Sanders, Thomas A. B.
Reidlinger, Dianne P.
Darzi, Julia
Berry, Sarah E. E.
Goff, Louise M.
Seed, Paul T.
Chowienczyk, Philip J.
Hall, Wendy L.
author_facet Govoni, Virginia
Sanders, Thomas A. B.
Reidlinger, Dianne P.
Darzi, Julia
Berry, Sarah E. E.
Goff, Louise M.
Seed, Paul T.
Chowienczyk, Philip J.
Hall, Wendy L.
author_sort Govoni, Virginia
collection PubMed
description PURPOSE: Healthy microcirculation is important to maintain the health of tissues and organs, most notably the heart, kidney and retina. Single components of the diet such as salt, lipids and polyphenols may influence microcirculation, but the effects of dietary patterns that are consistent with current dietary guidelines are uncertain. It was hypothesized that compliance to UK dietary guidelines would have a favourable effect on skin capillary density/recruitment compared with a traditional British diet (control diet). METHODS: A 12-week randomized controlled trial in men and women aged 40–70 years was used to test whether skin microcirculation, measured by skin video-capillaroscopy on the dorsum of the finger, influenced functional capillary density (number of capillaries perfused under basal conditions), structural capillary density (number of anatomical capillaries perfused during finger cuff inflation) and capillary recruitment (percentage difference between structural and functional capillary density). RESULTS: Microvascular measures were available for 137 subjects out of the 165 participants randomized to treatment. There was evidence of compliance to the dietary intervention, and participants randomized to follow dietary guidelines showed significant falls in resting supine systolic, diastolic and mean arterial pressure of 3.5, 2.6 and 2.9 mmHg compared to the control diet. There was no evidence of differences in capillary density, but capillary recruitment was 3.5 % (95 % CI 0.2, 6.9) greater (P = 0.04) on dietary guidelines compared with control. CONCLUSIONS: Adherence to dietary guidelines may help maintain a healthy microcirculation in middle-aged men and women. This study is registered at www.isrctn.com as ISRCTN92382106.
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spelling pubmed-53464142017-03-24 Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women Govoni, Virginia Sanders, Thomas A. B. Reidlinger, Dianne P. Darzi, Julia Berry, Sarah E. E. Goff, Louise M. Seed, Paul T. Chowienczyk, Philip J. Hall, Wendy L. Eur J Nutr Original Contribution PURPOSE: Healthy microcirculation is important to maintain the health of tissues and organs, most notably the heart, kidney and retina. Single components of the diet such as salt, lipids and polyphenols may influence microcirculation, but the effects of dietary patterns that are consistent with current dietary guidelines are uncertain. It was hypothesized that compliance to UK dietary guidelines would have a favourable effect on skin capillary density/recruitment compared with a traditional British diet (control diet). METHODS: A 12-week randomized controlled trial in men and women aged 40–70 years was used to test whether skin microcirculation, measured by skin video-capillaroscopy on the dorsum of the finger, influenced functional capillary density (number of capillaries perfused under basal conditions), structural capillary density (number of anatomical capillaries perfused during finger cuff inflation) and capillary recruitment (percentage difference between structural and functional capillary density). RESULTS: Microvascular measures were available for 137 subjects out of the 165 participants randomized to treatment. There was evidence of compliance to the dietary intervention, and participants randomized to follow dietary guidelines showed significant falls in resting supine systolic, diastolic and mean arterial pressure of 3.5, 2.6 and 2.9 mmHg compared to the control diet. There was no evidence of differences in capillary density, but capillary recruitment was 3.5 % (95 % CI 0.2, 6.9) greater (P = 0.04) on dietary guidelines compared with control. CONCLUSIONS: Adherence to dietary guidelines may help maintain a healthy microcirculation in middle-aged men and women. This study is registered at www.isrctn.com as ISRCTN92382106. Springer Berlin Heidelberg 2016-01-08 2017 /pmc/articles/PMC5346414/ /pubmed/26746219 http://dx.doi.org/10.1007/s00394-015-1151-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Contribution
Govoni, Virginia
Sanders, Thomas A. B.
Reidlinger, Dianne P.
Darzi, Julia
Berry, Sarah E. E.
Goff, Louise M.
Seed, Paul T.
Chowienczyk, Philip J.
Hall, Wendy L.
Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women
title Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women
title_full Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women
title_fullStr Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women
title_full_unstemmed Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women
title_short Compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women
title_sort compliance with dietary guidelines affects capillary recruitment in healthy middle-aged men and women
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346414/
https://www.ncbi.nlm.nih.gov/pubmed/26746219
http://dx.doi.org/10.1007/s00394-015-1151-3
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