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Thick Corpus Callosum in Children

BACKGROUND AND PURPOSE: A thick corpus callosum (TCC) can be associated with a very grave outcome in fetuses, but its clinical presentation in older children seems to be markedly different. METHODS: The corpus callosum (CC) was defined as thick based on observations and impressions. We reviewed case...

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Autores principales: Schupper, Aviv, Konen, Osnat, Halevy, Ayelet, Cohen, Rony, Aharoni, Sharon, Shuper, Avinoam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392459/
https://www.ncbi.nlm.nih.gov/pubmed/28406584
http://dx.doi.org/10.3988/jcn.2017.13.2.170
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author Schupper, Aviv
Konen, Osnat
Halevy, Ayelet
Cohen, Rony
Aharoni, Sharon
Shuper, Avinoam
author_facet Schupper, Aviv
Konen, Osnat
Halevy, Ayelet
Cohen, Rony
Aharoni, Sharon
Shuper, Avinoam
author_sort Schupper, Aviv
collection PubMed
description BACKGROUND AND PURPOSE: A thick corpus callosum (TCC) can be associated with a very grave outcome in fetuses, but its clinical presentation in older children seems to be markedly different. METHODS: The corpus callosum (CC) was defined as thick based on observations and impressions. We reviewed cases of children who were diagnosed as TCC based on brain magnetic resonance imaging (MRI) studies. The pertinent clinical data of these children were collected, and their CCs were measured. RESULTS: Out of 2,552 brain MRI images, those of 37 children were initially considered as showing a TCC. Those initial imaging were reviewed by an experienced neuroradiologist, who confirmed the diagnosis in 34 children (1.3%): 13 had neurofibromatosis-1 (NF-1), 9 had epilepsy, 3 had macrocephaly capillary malformation (MCM) syndrome, 3 had autistic spectrum disorder, 1 had a Chiari-1 malformation, and 1 had increased head circumference. No specific neurologic disorder could be defined in seven children. The measured thickness of the CC in these children was comparable to those published in the literature for adults. CONCLUSIONS: A TCC is a rare brain malformation that can be found in neuropathologies with apparently diverse pathognomonic mechanisms, such as NF-1 and MCM. It is not necessarily associated with life-threatening conditions, instead being a relatively benign finding, different in nature from that reported in fetuses.
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spelling pubmed-53924592017-04-17 Thick Corpus Callosum in Children Schupper, Aviv Konen, Osnat Halevy, Ayelet Cohen, Rony Aharoni, Sharon Shuper, Avinoam J Clin Neurol Original Article BACKGROUND AND PURPOSE: A thick corpus callosum (TCC) can be associated with a very grave outcome in fetuses, but its clinical presentation in older children seems to be markedly different. METHODS: The corpus callosum (CC) was defined as thick based on observations and impressions. We reviewed cases of children who were diagnosed as TCC based on brain magnetic resonance imaging (MRI) studies. The pertinent clinical data of these children were collected, and their CCs were measured. RESULTS: Out of 2,552 brain MRI images, those of 37 children were initially considered as showing a TCC. Those initial imaging were reviewed by an experienced neuroradiologist, who confirmed the diagnosis in 34 children (1.3%): 13 had neurofibromatosis-1 (NF-1), 9 had epilepsy, 3 had macrocephaly capillary malformation (MCM) syndrome, 3 had autistic spectrum disorder, 1 had a Chiari-1 malformation, and 1 had increased head circumference. No specific neurologic disorder could be defined in seven children. The measured thickness of the CC in these children was comparable to those published in the literature for adults. CONCLUSIONS: A TCC is a rare brain malformation that can be found in neuropathologies with apparently diverse pathognomonic mechanisms, such as NF-1 and MCM. It is not necessarily associated with life-threatening conditions, instead being a relatively benign finding, different in nature from that reported in fetuses. Korean Neurological Association 2017-04 2017-03-31 /pmc/articles/PMC5392459/ /pubmed/28406584 http://dx.doi.org/10.3988/jcn.2017.13.2.170 Text en Copyright © 2017 Korean Neurological Association http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Schupper, Aviv
Konen, Osnat
Halevy, Ayelet
Cohen, Rony
Aharoni, Sharon
Shuper, Avinoam
Thick Corpus Callosum in Children
title Thick Corpus Callosum in Children
title_full Thick Corpus Callosum in Children
title_fullStr Thick Corpus Callosum in Children
title_full_unstemmed Thick Corpus Callosum in Children
title_short Thick Corpus Callosum in Children
title_sort thick corpus callosum in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392459/
https://www.ncbi.nlm.nih.gov/pubmed/28406584
http://dx.doi.org/10.3988/jcn.2017.13.2.170
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