Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of microRNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human ca...

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Autores principales: Jiang, Lanfang, Zhao, Zitong, Zheng, Leilei, Xue, Liyan, Zhan, Qimin, Song, Yongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487524/
https://www.ncbi.nlm.nih.gov/pubmed/28602785
http://dx.doi.org/10.1016/j.gpb.2017.04.003
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author Jiang, Lanfang
Zhao, Zitong
Zheng, Leilei
Xue, Liyan
Zhan, Qimin
Song, Yongmei
author_facet Jiang, Lanfang
Zhao, Zitong
Zheng, Leilei
Xue, Liyan
Zhan, Qimin
Song, Yongmei
author_sort Jiang, Lanfang
collection PubMed
description Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of microRNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in ESCC remain undefined. In this study, we examined miR-503 expression by qPCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues. Further investigation in the effect of miR-503 on ESCC cell proliferation, migration, and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpression of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype. Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1.
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spelling pubmed-54875242017-07-12 Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1 Jiang, Lanfang Zhao, Zitong Zheng, Leilei Xue, Liyan Zhan, Qimin Song, Yongmei Genomics Proteomics Bioinformatics Original Research Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of microRNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in ESCC remain undefined. In this study, we examined miR-503 expression by qPCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues. Further investigation in the effect of miR-503 on ESCC cell proliferation, migration, and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpression of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype. Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1. Elsevier 2017-06 2017-06-09 /pmc/articles/PMC5487524/ /pubmed/28602785 http://dx.doi.org/10.1016/j.gpb.2017.04.003 Text en © 2017 Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Jiang, Lanfang
Zhao, Zitong
Zheng, Leilei
Xue, Liyan
Zhan, Qimin
Song, Yongmei
Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1
title Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1
title_full Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1
title_fullStr Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1
title_full_unstemmed Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1
title_short Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1
title_sort downregulation of mir-503 promotes escc cell proliferation, migration, and invasion by targeting cyclin d1
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487524/
https://www.ncbi.nlm.nih.gov/pubmed/28602785
http://dx.doi.org/10.1016/j.gpb.2017.04.003
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