Synthesis and evaluation of anthranilamide-based derivatives as FXa inhibitors

Factor Xa (FXa) plays a significant role in the blood coagulation cascade and is a promising target for anticoagulation drugs. Three oral FXa inhibitors have been approved by FDA for treating thrombotic diseases. In this study, 43 novel compounds were synthesized anthranilamide-based FXa inhibitors...

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Detalles Bibliográficos
Autores principales: Huang, Changjiang, Wang, Wenzhi, Li, Yao, Zhang, Shijun, Meng, Fancui, Xu, Weiren, Yuan, Jing, Chen, Ligong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514901/
https://www.ncbi.nlm.nih.gov/pubmed/28415603
http://dx.doi.org/10.18632/oncotarget.16427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514901/
https://www.ncbi.nlm.nih.gov/pubmed/28415603
http://dx.doi.org/10.18632/oncotarget.16427

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