MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway

Calcific aortic valve disease (CAVD) is the most common heart valve disorder, yet its mechanism remains poorly understood. Valve interstitial cells (VICs) are the prevalent cells in aortic valve and their osteogenic differentiation may be responsible for calcific nodule formation in CAVD pathogenesi...

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Detalles Bibliográficos
Autores principales: Xu, Rongjian, Zhao, Min, Yang, Yun, Huang, Zhuo, Shi, Chunying, Hou, Xianglin, Zhao, Yannan, Chen, Bing, Xiao, Zhifeng, Liu, Jianzhou, Miao, Qi, Dai, Jianwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562804/
https://www.ncbi.nlm.nih.gov/pubmed/28821833
http://dx.doi.org/10.1038/s41598-017-09390-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562804/
https://www.ncbi.nlm.nih.gov/pubmed/28821833
http://dx.doi.org/10.1038/s41598-017-09390-z

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