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NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children

Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, not clear whether this association reflects a chroni...

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Autores principales: Gesing, Julia, Scheuermann, Kathrin, Wagner, Isabel Viola, Löffler, Dennis, Friebe, Daniela, Kiess, Wieland, Schuster, Volker, Körner, Antje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570332/
https://www.ncbi.nlm.nih.gov/pubmed/28837586
http://dx.doi.org/10.1371/journal.pone.0183027
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author Gesing, Julia
Scheuermann, Kathrin
Wagner, Isabel Viola
Löffler, Dennis
Friebe, Daniela
Kiess, Wieland
Schuster, Volker
Körner, Antje
author_facet Gesing, Julia
Scheuermann, Kathrin
Wagner, Isabel Viola
Löffler, Dennis
Friebe, Daniela
Kiess, Wieland
Schuster, Volker
Körner, Antje
author_sort Gesing, Julia
collection PubMed
description Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, not clear whether this association reflects a chronic elevation or acute inflammatory response. We analyzed NAMPT concentrations in distinct states of inflammation in 102 children and found consistently significantly increased NAMPT levels in subjects with acute infections. NAMPT concentrations in children with stable chronic inflammatory diseases were not significantly different, whereas in patients with acute relapse of chronic disease NAMPT was significantly higher than in children in remission or healthy controls. In states of low-grade inflammation (children with atopic disease or obesity) we did not detect alterations in NAMPT serum levels. NAMPT correlated positively with inflammatory markers such as CRP. The most predictive factor for NAMPT serum concentrations was leucocyte count and therein the neutrophil count. Furthermore, systemic circulating NAMPT levels were closely associated with NAMPT release from corresponding cultured PBMCs. In conclusion, NAMPT is selectively increased in states of acute but not chronic inflammation in children. The close relationship between systemic circulating NAMPT with leucocyte counts and release indicate that leucocytes most probably are the source of inflammation related NAMPT levels.
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spelling pubmed-55703322017-09-09 NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children Gesing, Julia Scheuermann, Kathrin Wagner, Isabel Viola Löffler, Dennis Friebe, Daniela Kiess, Wieland Schuster, Volker Körner, Antje PLoS One Research Article Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, not clear whether this association reflects a chronic elevation or acute inflammatory response. We analyzed NAMPT concentrations in distinct states of inflammation in 102 children and found consistently significantly increased NAMPT levels in subjects with acute infections. NAMPT concentrations in children with stable chronic inflammatory diseases were not significantly different, whereas in patients with acute relapse of chronic disease NAMPT was significantly higher than in children in remission or healthy controls. In states of low-grade inflammation (children with atopic disease or obesity) we did not detect alterations in NAMPT serum levels. NAMPT correlated positively with inflammatory markers such as CRP. The most predictive factor for NAMPT serum concentrations was leucocyte count and therein the neutrophil count. Furthermore, systemic circulating NAMPT levels were closely associated with NAMPT release from corresponding cultured PBMCs. In conclusion, NAMPT is selectively increased in states of acute but not chronic inflammation in children. The close relationship between systemic circulating NAMPT with leucocyte counts and release indicate that leucocytes most probably are the source of inflammation related NAMPT levels. Public Library of Science 2017-08-24 /pmc/articles/PMC5570332/ /pubmed/28837586 http://dx.doi.org/10.1371/journal.pone.0183027 Text en © 2017 Gesing et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gesing, Julia
Scheuermann, Kathrin
Wagner, Isabel Viola
Löffler, Dennis
Friebe, Daniela
Kiess, Wieland
Schuster, Volker
Körner, Antje
NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children
title NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children
title_full NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children
title_fullStr NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children
title_full_unstemmed NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children
title_short NAMPT serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children
title_sort nampt serum levels are selectively elevated in acute infectious disease and in acute relapse of chronic inflammatory diseases in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570332/
https://www.ncbi.nlm.nih.gov/pubmed/28837586
http://dx.doi.org/10.1371/journal.pone.0183027
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