5-aza-2′-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells

High-risk human papillomaviruses (hr HPVs) may cause various human cancers and associated premalignant lesions. Transformation of the host cells is triggered by overexpression of the viral oncogenes E6 and E7 that deregulate the cell cycle and induce chromosomal instability. This process is accompan...

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Detalles Bibliográficos
Autores principales: Stich, Maximilian, Ganss, Lennard, Puschhof, Jens, Prigge, Elena-Sophie, Reuschenbach, Miriam, Guiterrez, Ana, Vinokurova, Svetlana, von Knebel Doeberitz, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581016/
https://www.ncbi.nlm.nih.gov/pubmed/28881717
http://dx.doi.org/10.18632/oncotarget.10631