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Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl(4)
A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl(4) is reported. The amidation reaction was performed in pyridine at 85 °C with a wide range of substrates providing the corresponding amide products in moderate to excel...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602818/ https://www.ncbi.nlm.nih.gov/pubmed/29086872 http://dx.doi.org/10.1186/s13065-017-0318-9 |