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Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl(4)

A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl(4) is reported. The amidation reaction was performed in pyridine at 85 °C with a wide range of substrates providing the corresponding amide products in moderate to excel...

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Detalles Bibliográficos
Autores principales: Leggio, Antonella, Bagalà, Jessica, Belsito, Emilia Lucia, Comandè, Alessandra, Greco, Marianna, Liguori, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602818/
https://www.ncbi.nlm.nih.gov/pubmed/29086872
http://dx.doi.org/10.1186/s13065-017-0318-9