Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core
Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618415/ https://www.ncbi.nlm.nih.gov/pubmed/28867803 http://dx.doi.org/10.3390/md15090276 |
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author | Carral-Menoyo, Asier Ortiz-de-Elguea, Verónica Martinez-Nunes, Mikel Sotomayor, Nuria Lete, Esther |
author_facet | Carral-Menoyo, Asier Ortiz-de-Elguea, Verónica Martinez-Nunes, Mikel Sotomayor, Nuria Lete, Esther |
author_sort | Carral-Menoyo, Asier |
collection | PubMed |
description | Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good yields via intramolecular C–H alkenylation reactions, by choosing the reaction conditions. This methodology provides a direct method for the construction of this type of quinoline through an efficient and atom economical procedure, and constitutes significant advance over the existing procedures that require preactivated reaction partners. |
format | Online Article Text |
id | pubmed-5618415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56184152017-09-30 Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core Carral-Menoyo, Asier Ortiz-de-Elguea, Verónica Martinez-Nunes, Mikel Sotomayor, Nuria Lete, Esther Mar Drugs Article Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good yields via intramolecular C–H alkenylation reactions, by choosing the reaction conditions. This methodology provides a direct method for the construction of this type of quinoline through an efficient and atom economical procedure, and constitutes significant advance over the existing procedures that require preactivated reaction partners. MDPI 2017-08-30 /pmc/articles/PMC5618415/ /pubmed/28867803 http://dx.doi.org/10.3390/md15090276 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carral-Menoyo, Asier Ortiz-de-Elguea, Verónica Martinez-Nunes, Mikel Sotomayor, Nuria Lete, Esther Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core |
title | Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core |
title_full | Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core |
title_fullStr | Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core |
title_full_unstemmed | Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core |
title_short | Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core |
title_sort | palladium-catalyzed dehydrogenative coupling: an efficient synthetic strategy for the construction of the quinoline core |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618415/ https://www.ncbi.nlm.nih.gov/pubmed/28867803 http://dx.doi.org/10.3390/md15090276 |
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