Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats

The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age perform...

Descripción completa

Detalles Bibliográficos
Autores principales: Stringhetta-Garcia, Camila Tami, Morais, Samuel Rodrigues Lourenço, Fernandes, Fernanda, Perez-Ueno, Melise Jacon, Almeida, Ricardo de Paula, Louzada, Mário Jefferson Quirino, Chaves-Neto, Antonio Hernandes, Ervolino, Edilson, Dornelles, Rita Cássia Menegati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663961/
https://www.ncbi.nlm.nih.gov/pubmed/29089563
http://dx.doi.org/10.1038/s41598-017-13098-5
_version_ 1783274909850402816
author Stringhetta-Garcia, Camila Tami
Morais, Samuel Rodrigues Lourenço
Fernandes, Fernanda
Perez-Ueno, Melise Jacon
Almeida, Ricardo de Paula
Louzada, Mário Jefferson Quirino
Chaves-Neto, Antonio Hernandes
Ervolino, Edilson
Dornelles, Rita Cássia Menegati
author_facet Stringhetta-Garcia, Camila Tami
Morais, Samuel Rodrigues Lourenço
Fernandes, Fernanda
Perez-Ueno, Melise Jacon
Almeida, Ricardo de Paula
Louzada, Mário Jefferson Quirino
Chaves-Neto, Antonio Hernandes
Ervolino, Edilson
Dornelles, Rita Cássia Menegati
author_sort Stringhetta-Garcia, Camila Tami
collection PubMed
description The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females.
format Online
Article
Text
id pubmed-5663961
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-56639612017-11-08 Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats Stringhetta-Garcia, Camila Tami Morais, Samuel Rodrigues Lourenço Fernandes, Fernanda Perez-Ueno, Melise Jacon Almeida, Ricardo de Paula Louzada, Mário Jefferson Quirino Chaves-Neto, Antonio Hernandes Ervolino, Edilson Dornelles, Rita Cássia Menegati Sci Rep Article The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females. Nature Publishing Group UK 2017-10-31 /pmc/articles/PMC5663961/ /pubmed/29089563 http://dx.doi.org/10.1038/s41598-017-13098-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Stringhetta-Garcia, Camila Tami
Morais, Samuel Rodrigues Lourenço
Fernandes, Fernanda
Perez-Ueno, Melise Jacon
Almeida, Ricardo de Paula
Louzada, Mário Jefferson Quirino
Chaves-Neto, Antonio Hernandes
Ervolino, Edilson
Dornelles, Rita Cássia Menegati
Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_full Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_fullStr Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_full_unstemmed Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_short Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
title_sort effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female wistar rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663961/
https://www.ncbi.nlm.nih.gov/pubmed/29089563
http://dx.doi.org/10.1038/s41598-017-13098-5
work_keys_str_mv AT stringhettagarciacamilatami effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT moraissamuelrodrigueslourenco effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT fernandesfernanda effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT perezuenomelisejacon effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT almeidaricardodepaula effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT louzadamariojeffersonquirino effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT chavesnetoantoniohernandes effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT ervolinoedilson effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats
AT dornellesritacassiamenegati effectsofstrengthtrainingandraloxifeneonfemoralneckmetabolismandmicroarchitectureofagingfemalewistarrats