Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats
The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age perform...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663961/ https://www.ncbi.nlm.nih.gov/pubmed/29089563 http://dx.doi.org/10.1038/s41598-017-13098-5 |
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author | Stringhetta-Garcia, Camila Tami Morais, Samuel Rodrigues Lourenço Fernandes, Fernanda Perez-Ueno, Melise Jacon Almeida, Ricardo de Paula Louzada, Mário Jefferson Quirino Chaves-Neto, Antonio Hernandes Ervolino, Edilson Dornelles, Rita Cássia Menegati |
author_facet | Stringhetta-Garcia, Camila Tami Morais, Samuel Rodrigues Lourenço Fernandes, Fernanda Perez-Ueno, Melise Jacon Almeida, Ricardo de Paula Louzada, Mário Jefferson Quirino Chaves-Neto, Antonio Hernandes Ervolino, Edilson Dornelles, Rita Cássia Menegati |
author_sort | Stringhetta-Garcia, Camila Tami |
collection | PubMed |
description | The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females. |
format | Online Article Text |
id | pubmed-5663961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56639612017-11-08 Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats Stringhetta-Garcia, Camila Tami Morais, Samuel Rodrigues Lourenço Fernandes, Fernanda Perez-Ueno, Melise Jacon Almeida, Ricardo de Paula Louzada, Mário Jefferson Quirino Chaves-Neto, Antonio Hernandes Ervolino, Edilson Dornelles, Rita Cássia Menegati Sci Rep Article The aim of this study was to prevent female osteoporosis using strength training (ST), raloxifene (Ral) or a combination of ST plus Ral during the natural female aging process, specifically in the periestropause period. For a total of 120 days, aging female Wistar rats at 18-21 months of age performed ST on a ladder three times per week, and Ral was administered daily by gavage (1 mg/kg/day). Bone microarchitecture, areal bone mineral density, bone strength of the femoral neck, immunohistochemistry, osteoclast and osteoblast surface were assessed. We found that the treatments modulate the bone remodeling cycle in different ways. Both ST and Ral treatment resulted in improved bone microarchitecture in the femoral neck of rats in late periestropause. However, only ST improved cortical microarchitecture and bone strength in the femoral neck. Thus, we suggest that performing ST during the late period of periestropause is a valid intervention to prevent age-associated osteoporosis in females. Nature Publishing Group UK 2017-10-31 /pmc/articles/PMC5663961/ /pubmed/29089563 http://dx.doi.org/10.1038/s41598-017-13098-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Stringhetta-Garcia, Camila Tami Morais, Samuel Rodrigues Lourenço Fernandes, Fernanda Perez-Ueno, Melise Jacon Almeida, Ricardo de Paula Louzada, Mário Jefferson Quirino Chaves-Neto, Antonio Hernandes Ervolino, Edilson Dornelles, Rita Cássia Menegati Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats |
title | Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats |
title_full | Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats |
title_fullStr | Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats |
title_full_unstemmed | Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats |
title_short | Effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female Wistar rats |
title_sort | effects of strength training and raloxifene on femoral neck metabolism and microarchitecture of aging female wistar rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663961/ https://www.ncbi.nlm.nih.gov/pubmed/29089563 http://dx.doi.org/10.1038/s41598-017-13098-5 |
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