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Regulation of human and mouse telomerase genes by genomic contexts and transcription factors during embryonic stem cell differentiation
Differential regulation of telomerase reverse transcriptase (TERT) genes contribute to distinct aging and tumorigenic processes in humans and mice. To study TERT regulation, we generated mouse embryonic stem cell (ESC) lines containing single-copy bacterial artificial chromosome (BAC) reporters, cov...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703907/ https://www.ncbi.nlm.nih.gov/pubmed/29180668 http://dx.doi.org/10.1038/s41598-017-16764-w |