Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

Senescence is a terminal differentiation program that halts the growth of damaged cells and must be circumvented for cancer to arise. Here we describe a panel of genetic screens to identify genes required for replicative senescence. We uncover a role in senescence for the potent tumor suppressor and...

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Detalles Bibliográficos
Autores principales: Mazzucco, Anna E., Smogorzewska, Agata, Kang, Chanhee, Luo, Ji, Schlabach, Michael R., Xu, Qikai, Patel, Rupesh, Elledge, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710139/
https://www.ncbi.nlm.nih.gov/pubmed/29089421
http://dx.doi.org/10.1101/gad.304857.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710139/
https://www.ncbi.nlm.nih.gov/pubmed/29089421
http://dx.doi.org/10.1101/gad.304857.117

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