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Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc engineering, IgG-FcRn interaction can be used to generate a variety of therapeutic antibodies with significantly enhanced h...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Higher Education Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777971/ https://www.ncbi.nlm.nih.gov/pubmed/28421387 http://dx.doi.org/10.1007/s13238-017-0408-4 |