Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

Huntington’s disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and t...

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Detalles Bibliográficos
Autores principales: Dargaei, Zahra, Bang, Jee Yoon, Mahadevan, Vivek, Khademullah, C. Sahara, Bedard, Simon, Parfitt, Gustavo Morrone, Kim, Jun Chul, Woodin, Melanie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816181/
https://www.ncbi.nlm.nih.gov/pubmed/29382760
http://dx.doi.org/10.1073/pnas.1716871115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816181/
https://www.ncbi.nlm.nih.gov/pubmed/29382760
http://dx.doi.org/10.1073/pnas.1716871115

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