Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5, which has good selectivity over the RARβ, and RARγ receptors. Analysis of...

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Detalles Bibliográficos
Autores principales: Clarke, Earl, Jarvis, Christopher I., Goncalves, Maria B., Kalindjian, S. Barret, Adams, David R., Brown, Jane T., Shiers, Jason J., Taddei, David M.A., Ravier, Elodie, Barlow, Stephanie, Miller, Iain, Smith, Vanessa, Borthwick, Alan D., Corcoran, Jonathan P.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823845/
https://www.ncbi.nlm.nih.gov/pubmed/29288071
http://dx.doi.org/10.1016/j.bmc.2017.12.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823845/
https://www.ncbi.nlm.nih.gov/pubmed/29288071
http://dx.doi.org/10.1016/j.bmc.2017.12.015

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