Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways

Simulated microgravity (SMG) was reported to affect tumor cell proliferation and metastasis. However, the underlying mechanism is elusive. In this study, we demonstrate that clinostat-modelled SMG reduces BL6-10 melanoma cell proliferation, adhesion and invasiveness in vitro and decreases tumor lung...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Xin, Xu, Aizhang, Zhao, Tuo, Zhao, Qin, Zhang, Jun, Fan, Cuihong, Deng, Yulin, Freywald, Andrew, Genth, Harald, Xiang, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830577/
https://www.ncbi.nlm.nih.gov/pubmed/29491429
http://dx.doi.org/10.1038/s41598-018-20459-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830577/
https://www.ncbi.nlm.nih.gov/pubmed/29491429
http://dx.doi.org/10.1038/s41598-018-20459-1

Ejemplares similares