Use of weighted multivariate estimates in trials of multi-serotype vaccines to simplify interpretation of treatment differences

BACKGROUND: Many vaccines contain multiple components. Licensed pneumococcal conjugate vaccines (PCV) contain polysaccharides from 7, 10, or 13 different serotypes of Streptococcus pneumoniae. The main outcomes in randomised trials of pneumococcal vaccines are serotype-specific antibody measures. Co...

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Detalles Bibliográficos
Autores principales: Voysey, Merryn, Pollard, Andrew J., Perera, Rafael, Shrestha, Shrijana, Thorson, Stephen, Fanshawe, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922548/
https://www.ncbi.nlm.nih.gov/pubmed/29702658
http://dx.doi.org/10.1371/journal.pone.0196200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922548/
https://www.ncbi.nlm.nih.gov/pubmed/29702658
http://dx.doi.org/10.1371/journal.pone.0196200

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