The genetics of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting...

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Detalles Bibliográficos
Autores principales: Lomas, David A, Silverman, Edwin K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59565/
https://www.ncbi.nlm.nih.gov/pubmed/11686861
http://dx.doi.org/10.1186/rr34
Descripción
Sumario:Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity and mortality. Previous studies have shown that COPD aggregates in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting. We review the genetic factors that predispose smokers to COPD and highlight the future role of genomic scans in identifying novel susceptibility genes.

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