Deducing the presence of proteins and proteoforms in quantitative proteomics

The human genome harbors just 20,000 genes suggesting that the variety of possible protein products per gene plays a significant role in generating functional diversity. In bottom-up proteomics peptides are mapped back to proteins and proteoforms to describe a proteome; however, accurate quantitatio...

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Detalles Bibliográficos
Autores principales: Bamberger, Casimir, Martínez-Bartolomé, Salvador, Montgomery, Miranda, Pankow, Sandra, Hulleman, John D., Kelly, Jeffery W., Yates, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998138/
https://www.ncbi.nlm.nih.gov/pubmed/29899466
http://dx.doi.org/10.1038/s41467-018-04411-5