N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis. Herein, DMHCA was evaluated for its retinal effects on normal C57BL/6J and Cyp27a1(−/−)Cyp46a1(−/−) mice; the latter havin...

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Detalles Bibliográficos
Autores principales: El-Darzi, Nicole, Astafev, Artem, Mast, Natalia, Saadane, Aicha, Lam, Morrie, Pikuleva, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069453/
https://www.ncbi.nlm.nih.gov/pubmed/30090064
http://dx.doi.org/10.3389/fphar.2018.00827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069453/
https://www.ncbi.nlm.nih.gov/pubmed/30090064
http://dx.doi.org/10.3389/fphar.2018.00827

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