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Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
A cobalt-catalyzed C(sp(2))–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122339/ https://www.ncbi.nlm.nih.gov/pubmed/30202462 http://dx.doi.org/10.3762/bjoc.14.183 |
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author | Han, Jiao-Na Du, Cong Zhu, Xinju Wang, Zheng-Long Zhu, Yue Chu, Zhao-Yang Niu, Jun-Long Song, Mao-Ping |
author_facet | Han, Jiao-Na Du, Cong Zhu, Xinju Wang, Zheng-Long Zhu, Yue Chu, Zhao-Yang Niu, Jun-Long Song, Mao-Ping |
author_sort | Han, Jiao-Na |
collection | PubMed |
description | A cobalt-catalyzed C(sp(2))–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group. |
format | Online Article Text |
id | pubmed-6122339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-61223392018-09-10 Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives Han, Jiao-Na Du, Cong Zhu, Xinju Wang, Zheng-Long Zhu, Yue Chu, Zhao-Yang Niu, Jun-Long Song, Mao-Ping Beilstein J Org Chem Letter A cobalt-catalyzed C(sp(2))–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group. Beilstein-Institut 2018-08-09 /pmc/articles/PMC6122339/ /pubmed/30202462 http://dx.doi.org/10.3762/bjoc.14.183 Text en Copyright © 2018, Han et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Letter Han, Jiao-Na Du, Cong Zhu, Xinju Wang, Zheng-Long Zhu, Yue Chu, Zhao-Yang Niu, Jun-Long Song, Mao-Ping Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives |
title | Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives |
title_full | Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives |
title_fullStr | Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives |
title_full_unstemmed | Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives |
title_short | Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives |
title_sort | cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122339/ https://www.ncbi.nlm.nih.gov/pubmed/30202462 http://dx.doi.org/10.3762/bjoc.14.183 |
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