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Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives

A cobalt-catalyzed C(sp(2))–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and...

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Autores principales: Han, Jiao-Na, Du, Cong, Zhu, Xinju, Wang, Zheng-Long, Zhu, Yue, Chu, Zhao-Yang, Niu, Jun-Long, Song, Mao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122339/
https://www.ncbi.nlm.nih.gov/pubmed/30202462
http://dx.doi.org/10.3762/bjoc.14.183
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author Han, Jiao-Na
Du, Cong
Zhu, Xinju
Wang, Zheng-Long
Zhu, Yue
Chu, Zhao-Yang
Niu, Jun-Long
Song, Mao-Ping
author_facet Han, Jiao-Na
Du, Cong
Zhu, Xinju
Wang, Zheng-Long
Zhu, Yue
Chu, Zhao-Yang
Niu, Jun-Long
Song, Mao-Ping
author_sort Han, Jiao-Na
collection PubMed
description A cobalt-catalyzed C(sp(2))–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group.
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spelling pubmed-61223392018-09-10 Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives Han, Jiao-Na Du, Cong Zhu, Xinju Wang, Zheng-Long Zhu, Yue Chu, Zhao-Yang Niu, Jun-Long Song, Mao-Ping Beilstein J Org Chem Letter A cobalt-catalyzed C(sp(2))–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group. Beilstein-Institut 2018-08-09 /pmc/articles/PMC6122339/ /pubmed/30202462 http://dx.doi.org/10.3762/bjoc.14.183 Text en Copyright © 2018, Han et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Han, Jiao-Na
Du, Cong
Zhu, Xinju
Wang, Zheng-Long
Zhu, Yue
Chu, Zhao-Yang
Niu, Jun-Long
Song, Mao-Ping
Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
title Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
title_full Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
title_fullStr Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
title_full_unstemmed Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
title_short Cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
title_sort cobalt-catalyzed peri-selective alkoxylation of 1-naphthylamine derivatives
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122339/
https://www.ncbi.nlm.nih.gov/pubmed/30202462
http://dx.doi.org/10.3762/bjoc.14.183
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