Functional brain network centrality is related to APOE genotype in cognitively normal elderly
INTRODUCTION: Amyloid plaque deposition in the brain is an early pathological change in Alzheimer's disease (AD), causing disrupted synaptic connections. Brain network disruptions in AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within net...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160659/ https://www.ncbi.nlm.nih.gov/pubmed/30136422 http://dx.doi.org/10.1002/brb3.1080 |
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author | Wink, Alle Meije Tijms, Betty M. ten Kate, Mara Raspor, Eva de Munck, Jan C. Altena, Ellemarije Ecay‐Torres, Mirian Clerigue, Montserrat Estanga, Ainara Garcia‐Sebastian, Maite Izagirre, Andrea Martinez‐Lage Alvarez, Pablo Villanua, Jorge Barkhof, Frederik Sanz‐Arigita, Ernesto |
author_facet | Wink, Alle Meije Tijms, Betty M. ten Kate, Mara Raspor, Eva de Munck, Jan C. Altena, Ellemarije Ecay‐Torres, Mirian Clerigue, Montserrat Estanga, Ainara Garcia‐Sebastian, Maite Izagirre, Andrea Martinez‐Lage Alvarez, Pablo Villanua, Jorge Barkhof, Frederik Sanz‐Arigita, Ernesto |
author_sort | Wink, Alle Meije |
collection | PubMed |
description | INTRODUCTION: Amyloid plaque deposition in the brain is an early pathological change in Alzheimer's disease (AD), causing disrupted synaptic connections. Brain network disruptions in AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within networks. Carrying an apolipoprotein (APOE)‐ε4 allele is a genetic risk for AD, associated with increased amyloid deposition. We studied whether APOE‐ε4 carriership is associated with EC disruptions in cognitively normal individuals. METHODS: A total of 261 healthy middle‐aged to older adults (mean age 56.6 years) were divided into high‐risk (APOE‐ε4 carriers) and low‐risk (noncarriers) groups. EC was computed from resting‐state functional MRI data. Clusters of between‐group differences were assessed with a permutation‐based method. Correlations between cluster mean EC with brain volume, CSF biomarkers, and psychological test scores were assessed. RESULTS: Decreased EC in the visual cortex was associated with APOE‐ε4 carriership, a genetic risk factor for AD. EC differences were correlated with age, CSF amyloid levels, and scores on the trail‐making and 15‐object recognition tests. CONCLUSION: Our findings suggest that the APOE‐ε4 genotype affects brain connectivity in regions previously found to be abnormal in AD as a sign of very early disease‐related pathology. These differences were too subtle in healthy elderly to use EC for single‐subject prediction of APOE genotype. |
format | Online Article Text |
id | pubmed-6160659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61606592018-10-01 Functional brain network centrality is related to APOE genotype in cognitively normal elderly Wink, Alle Meije Tijms, Betty M. ten Kate, Mara Raspor, Eva de Munck, Jan C. Altena, Ellemarije Ecay‐Torres, Mirian Clerigue, Montserrat Estanga, Ainara Garcia‐Sebastian, Maite Izagirre, Andrea Martinez‐Lage Alvarez, Pablo Villanua, Jorge Barkhof, Frederik Sanz‐Arigita, Ernesto Brain Behav Original Research INTRODUCTION: Amyloid plaque deposition in the brain is an early pathological change in Alzheimer's disease (AD), causing disrupted synaptic connections. Brain network disruptions in AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within networks. Carrying an apolipoprotein (APOE)‐ε4 allele is a genetic risk for AD, associated with increased amyloid deposition. We studied whether APOE‐ε4 carriership is associated with EC disruptions in cognitively normal individuals. METHODS: A total of 261 healthy middle‐aged to older adults (mean age 56.6 years) were divided into high‐risk (APOE‐ε4 carriers) and low‐risk (noncarriers) groups. EC was computed from resting‐state functional MRI data. Clusters of between‐group differences were assessed with a permutation‐based method. Correlations between cluster mean EC with brain volume, CSF biomarkers, and psychological test scores were assessed. RESULTS: Decreased EC in the visual cortex was associated with APOE‐ε4 carriership, a genetic risk factor for AD. EC differences were correlated with age, CSF amyloid levels, and scores on the trail‐making and 15‐object recognition tests. CONCLUSION: Our findings suggest that the APOE‐ε4 genotype affects brain connectivity in regions previously found to be abnormal in AD as a sign of very early disease‐related pathology. These differences were too subtle in healthy elderly to use EC for single‐subject prediction of APOE genotype. John Wiley and Sons Inc. 2018-08-22 /pmc/articles/PMC6160659/ /pubmed/30136422 http://dx.doi.org/10.1002/brb3.1080 Text en © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Wink, Alle Meije Tijms, Betty M. ten Kate, Mara Raspor, Eva de Munck, Jan C. Altena, Ellemarije Ecay‐Torres, Mirian Clerigue, Montserrat Estanga, Ainara Garcia‐Sebastian, Maite Izagirre, Andrea Martinez‐Lage Alvarez, Pablo Villanua, Jorge Barkhof, Frederik Sanz‐Arigita, Ernesto Functional brain network centrality is related to APOE genotype in cognitively normal elderly |
title | Functional brain network centrality is related to APOE genotype in cognitively normal elderly |
title_full | Functional brain network centrality is related to APOE genotype in cognitively normal elderly |
title_fullStr | Functional brain network centrality is related to APOE genotype in cognitively normal elderly |
title_full_unstemmed | Functional brain network centrality is related to APOE genotype in cognitively normal elderly |
title_short | Functional brain network centrality is related to APOE genotype in cognitively normal elderly |
title_sort | functional brain network centrality is related to apoe genotype in cognitively normal elderly |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160659/ https://www.ncbi.nlm.nih.gov/pubmed/30136422 http://dx.doi.org/10.1002/brb3.1080 |
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