Species generalization and differences in Hedgehog pathway regulation of fungiform and circumvallate papilla taste function and somatosensation demonstrated with sonidegib

Species generalization in the profound, modality-specific effects of Hedgehog pathway inhibition (HPI) in taste organ homeostasis and sensation is shown. With the HPI, cancer drug sonidegib, we demonstrate that the rat taste system, in addition to mouse, is regulated by Hedgehog signaling. After son...

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Detalles Bibliográficos
Autores principales: Kumari, A., Yokota, Y., Li, L., Bradley, R. M., Mistretta, C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212413/
https://www.ncbi.nlm.nih.gov/pubmed/30385780
http://dx.doi.org/10.1038/s41598-018-34399-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212413/
https://www.ncbi.nlm.nih.gov/pubmed/30385780
http://dx.doi.org/10.1038/s41598-018-34399-3

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