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Species generalization and differences in Hedgehog pathway regulation of fungiform and circumvallate papilla taste function and somatosensation demonstrated with sonidegib

Species generalization in the profound, modality-specific effects of Hedgehog pathway inhibition (HPI) in taste organ homeostasis and sensation is shown. With the HPI, cancer drug sonidegib, we demonstrate that the rat taste system, in addition to mouse, is regulated by Hedgehog signaling. After son...

詳細記述

書誌詳細
主要な著者: Kumari, A., Yokota, Y., Li, L., Bradley, R. M., Mistretta, C. M.
フォーマット: Online 論文 テキスト
言語:English
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212413/
https://www.ncbi.nlm.nih.gov/pubmed/30385780
http://dx.doi.org/10.1038/s41598-018-34399-3