Molecular Recognition of Parallel G-quadruplex [d-(TTGGGGT)](4) Containing Tetrahymena Telomeric DNA Sequence by Anticancer Drug Daunomycin: NMR-Based Structure and Thermal Stability

The anticancer drug daunomycin exerts its influence by multiple strategies of action to interfere with gene functioning. Besides inhibiting DNA/RNA synthesis and topoisomerase-II, it affects the functional pathway of telomere maintenance by the telomerase enzyme. We present evidence of the binding o...

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Detalles Bibliográficos
Autores principales: Barthwal, Ritu, Tariq, Zia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225185/
https://www.ncbi.nlm.nih.gov/pubmed/30189644
http://dx.doi.org/10.3390/molecules23092266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225185/
https://www.ncbi.nlm.nih.gov/pubmed/30189644
http://dx.doi.org/10.3390/molecules23092266

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