Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer

BACKGROUND: Pancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion is present. Accurate evaluation of presence of vascular invasion can help guide therapy. The aim of this study was to construct a nomogram for preoperative prediction of peripancreatic vein...

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Autores principales: Shen, Yi-Nan, Guo, Cheng-Xiang, Pan, Yao, Chen, Yi-Wen, Tang, Tian-Yu, Li, Yu-Wei, Lu, Jun-Hua, Jin, Gang, Qin, Ren-Yi, Yao, Wei-Yun, Liang, Ting-Bo, Bai, Xue-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288927/
https://www.ncbi.nlm.nih.gov/pubmed/30526690
http://dx.doi.org/10.1186/s40644-018-0179-z
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author Shen, Yi-Nan
Guo, Cheng-Xiang
Pan, Yao
Chen, Yi-Wen
Tang, Tian-Yu
Li, Yu-Wei
Lu, Jun-Hua
Jin, Gang
Qin, Ren-Yi
Yao, Wei-Yun
Liang, Ting-Bo
Bai, Xue-Li
author_facet Shen, Yi-Nan
Guo, Cheng-Xiang
Pan, Yao
Chen, Yi-Wen
Tang, Tian-Yu
Li, Yu-Wei
Lu, Jun-Hua
Jin, Gang
Qin, Ren-Yi
Yao, Wei-Yun
Liang, Ting-Bo
Bai, Xue-Li
author_sort Shen, Yi-Nan
collection PubMed
description BACKGROUND: Pancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion is present. Accurate evaluation of presence of vascular invasion can help guide therapy. The aim of this study was to construct a nomogram for preoperative prediction of peripancreatic vein invasion in patients with pancreatic head cancer. STUDY DESIGN: Data of patients with carcinoma head of pancreas and suspected peripancreatic invasion (n = 247) who underwent pancreatic resection with venous reconstruction between January 2012 and January 2017 at four academic institutions were retrospectively analyzed. Univariate and multivariate analyses were used to identify independent risk factors for vein invasion from among demographic, biological, conditional host-related, and anatomical data. A predictive nomogram was constructed based on the identified independent risk factors. RESULTS: The nomogram was constructed using data from 181 patients while the validation cohort consisted of 66 patients. Length of tumor contact (P = 0.031), circumferential vein involvement (P = 0.048), and venous contour abnormalities (P = 0.001) were independent predictors of venous invasion. The C-index of the model in predicting venous invasion was 0.963 for the external validation cohort. Patients could be assigned into low- (< 50%), intermediate- (50–90%), and high-risk (> 90%) groups based on the nomogram to facilitate personalized management. CONCLUSIONS: Vein invasion by pancreatic head cancer is mainly associated with anatomical factors. The nomogram for prediction of vein invasion was found to be practicable. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40644-018-0179-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-62889272018-12-14 Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer Shen, Yi-Nan Guo, Cheng-Xiang Pan, Yao Chen, Yi-Wen Tang, Tian-Yu Li, Yu-Wei Lu, Jun-Hua Jin, Gang Qin, Ren-Yi Yao, Wei-Yun Liang, Ting-Bo Bai, Xue-Li Cancer Imaging Research Article BACKGROUND: Pancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion is present. Accurate evaluation of presence of vascular invasion can help guide therapy. The aim of this study was to construct a nomogram for preoperative prediction of peripancreatic vein invasion in patients with pancreatic head cancer. STUDY DESIGN: Data of patients with carcinoma head of pancreas and suspected peripancreatic invasion (n = 247) who underwent pancreatic resection with venous reconstruction between January 2012 and January 2017 at four academic institutions were retrospectively analyzed. Univariate and multivariate analyses were used to identify independent risk factors for vein invasion from among demographic, biological, conditional host-related, and anatomical data. A predictive nomogram was constructed based on the identified independent risk factors. RESULTS: The nomogram was constructed using data from 181 patients while the validation cohort consisted of 66 patients. Length of tumor contact (P = 0.031), circumferential vein involvement (P = 0.048), and venous contour abnormalities (P = 0.001) were independent predictors of venous invasion. The C-index of the model in predicting venous invasion was 0.963 for the external validation cohort. Patients could be assigned into low- (< 50%), intermediate- (50–90%), and high-risk (> 90%) groups based on the nomogram to facilitate personalized management. CONCLUSIONS: Vein invasion by pancreatic head cancer is mainly associated with anatomical factors. The nomogram for prediction of vein invasion was found to be practicable. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40644-018-0179-z) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-10 /pmc/articles/PMC6288927/ /pubmed/30526690 http://dx.doi.org/10.1186/s40644-018-0179-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Shen, Yi-Nan
Guo, Cheng-Xiang
Pan, Yao
Chen, Yi-Wen
Tang, Tian-Yu
Li, Yu-Wei
Lu, Jun-Hua
Jin, Gang
Qin, Ren-Yi
Yao, Wei-Yun
Liang, Ting-Bo
Bai, Xue-Li
Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer
title Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer
title_full Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer
title_fullStr Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer
title_full_unstemmed Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer
title_short Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer
title_sort preoperative prediction of peripancreatic vein invasion by pancreatic head cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288927/
https://www.ncbi.nlm.nih.gov/pubmed/30526690
http://dx.doi.org/10.1186/s40644-018-0179-z
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