Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators

Acid-sensing ion channels (ASICs) belong to the DEG/ENaC gene family. While ASIC1a, ASIC1b and ASIC3 are activated by extracellular protons, ASIC4 and the closely related bile acid-sensitive ion channel (BASIC or ASIC5) are orphan receptors. Neuropeptides are important modulators of ASICs. Moreover,...

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Detalles Bibliográficos
Autores principales: Vyvers, Anna, Schmidt, Axel, Wiemuth, Dominik, Gründer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301962/
https://www.ncbi.nlm.nih.gov/pubmed/30573735
http://dx.doi.org/10.1038/s41598-018-36125-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301962/
https://www.ncbi.nlm.nih.gov/pubmed/30573735
http://dx.doi.org/10.1038/s41598-018-36125-5

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