Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling

DNA double-strand breaks (DSBs) jeopardize genome integrity and can—when repaired unfaithfully—give rise to structural rearrangements associated with cancer. Exogenous agents such as ionizing radiation or chemotherapy can invoke DSBs, but a vast amount of breakage arises during vital endogenous DNA...

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Detalles Bibliográficos
Autores principales: Bouwman, Britta A. M., Crosetto, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316733/
https://www.ncbi.nlm.nih.gov/pubmed/30558210
http://dx.doi.org/10.3390/genes9120632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316733/
https://www.ncbi.nlm.nih.gov/pubmed/30558210
http://dx.doi.org/10.3390/genes9120632

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