The density of Tbet+ tumor-infiltrating T lymphocytes reflects an effective and druggable preexisting adaptive antitumor immune response in colorectal cancer, irrespective of the microsatellite status

Purpose: The recent success of anti-PD1 antibody in metastatic colorectal cancer (CRC) patients with microsatellite instability (MSI), known to be associated with an upregulated Th1/Tc1 gene signature, provides new promising therapeutic strategies. However, the partial objective response highlights...

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Detalles Bibliográficos
Autores principales: Ott, Eva, Bilonda, Linda, Dansette, Delphine, Deleine, Cécile, Duchalais, Emilie, Podevin, Juliette, Volteau, Christelle, Bennouna, Jaafar, Touchefeu, Yann, Fourquier, Pierre, El Alami Thomas, Wassila, Chetritt, Jérome, Bezieau, Stéphane, Denis, Marc, Toquet, Claire, Mosnier, Jean-François, Jarry, Anne, Bossard, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422378/
https://www.ncbi.nlm.nih.gov/pubmed/30906656
http://dx.doi.org/10.1080/2162402X.2018.1562834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422378/
https://www.ncbi.nlm.nih.gov/pubmed/30906656
http://dx.doi.org/10.1080/2162402X.2018.1562834

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