Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation

A small library of new drug-1,3,4-thiazidazole hybrid compounds (3a–3i) was synthesized, characterized, and assessed for their acetyl cholinesterase enzyme (AChE) inhibitory and free radical scavenging activities. The newly synthesized derivatives showed promising activities against AChE, especially...

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Detalles Bibliográficos
Autores principales: Ujan, Rabail, Saeed, Aamer, Channar, Pervaiz Ali, Larik, Fayaz Ali, Abbas, Qamar, Alajmi, Mohamed F., El-Seedi, Hesham R., Rind, Mahboob Ali, Hassan, Mubashir, Raza, Hussain, Seo, Sung-Yum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429202/
https://www.ncbi.nlm.nih.gov/pubmed/30823444
http://dx.doi.org/10.3390/molecules24050860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429202/
https://www.ncbi.nlm.nih.gov/pubmed/30823444
http://dx.doi.org/10.3390/molecules24050860

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