Dengue seroprevalence among asymptomatic blood donors during an epidemic outbreak in Central-West Brazil

Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serol...

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Detalles Bibliográficos
Autores principales: Slavov, Svetoslav Nanev, Cilião-Alves, Daiani Cristina, Gonzaga, Filipe Almeida Carvalho, Moura, Drielly Rodrigues, de Moura, Ana Carolina Alves Melo, de Noronha, Lorena Aparecida Gonçalves, Cassemiro, Évelin Mota, Pimentel, Bárbara Maciel Sidou, Costa, Fabiano José Queiroz, da Silva, Grasiela Araújo, Ramos, Doralina do Amaral Rabello, de Araújo, Wildo Navegantes, Kashima, Simone, Haddad, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433220/
https://www.ncbi.nlm.nih.gov/pubmed/30908528
http://dx.doi.org/10.1371/journal.pone.0213793
Descripción
Sumario:Dengue virus (DENV) transmission by blood transfusion is an important route of viral acquisition during outbreaks. The prevalence of DENV markers (viral RNA, NS1, anti-DENV IgM, and IgG) among blood donors in Central-West Brazil has never been evaluated. Our aim was to evaluate the full set of serological and molecular markers for DENV among blood donors of the Federal District of Brazil during an extensive outbreak in 2016. We found an anti-DENV IgM prevalence of 6.74% (n = 32/475). Of 475, 20 samples (4.21%) were also anti-DENV IgG positive. All samples were non-reactive for NS1 and DENV RNA. Our results imply that a significant proportion of the tested donors had experienced asymptomatic infection. More studies are necessary to evaluate the real prevalence of DENV viremia in blood donors from the Federal District of Brazil and if specific measures are needed to routinely test the blood donors for DENV RNA during outbreaks.