Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

The aggregates of the Aβ peptide associated with Alzheimer’s disease are able to both grow in size as well as generate, through secondary nucleation, new small oligomeric species, that are major cytotoxins associated with neuronal death. Despite the importance of these amyloid fibril-dependent proce...

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Detalles Bibliográficos
Autores principales: Scheidt, Tom, Łapińska, Urszula, Kumita, Janet R., Whiten, Daniel R., Klenerman, David, Wilson, Mark R., Cohen, Samuel I. A., Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M., Knowles, Tuomas P. J., Arosio, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469941/
https://www.ncbi.nlm.nih.gov/pubmed/31001578
http://dx.doi.org/10.1126/sciadv.aau3112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469941/
https://www.ncbi.nlm.nih.gov/pubmed/31001578
http://dx.doi.org/10.1126/sciadv.aau3112

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