Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII

Novel sulfonamidoindole-based hydrazones with a 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide scaffold were synthesized and tested in enzyme inhibition assays against the tumor-associated carbonic anhydrase isoforms, hCA IX and XII, and the off-targets, hCA I and II. The compounds showed se...

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Detalles Bibliográficos
Autores principales: Demir-Yazıcı, Kübra, Bua, Silvia, Akgüneş, Nurgül Mutlu, Akdemir, Atilla, Supuran, Claudiu T., Güzel-Akdemir, Özlen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539891/
https://www.ncbi.nlm.nih.gov/pubmed/31083645
http://dx.doi.org/10.3390/ijms20092354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539891/
https://www.ncbi.nlm.nih.gov/pubmed/31083645
http://dx.doi.org/10.3390/ijms20092354

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